Hubungan Kolelitiasis dengan Kadar Bilirubin Total, Gamma Glutamyl Transferase dan Alkaline Phosphatase

Nadhira Yasmin; Agustyas Tjiptanigrum

doi:10.37287/jppp.v7i3.6748

Nadhira Yasmin Universitas Lampung
Agustyas Tjiptanigrum Universitas Lampung

DOI: https://doi.org/10.37287/jppp.v7i3.6748

Keywords: alkaline phosphatase, bilirubin total, gamma glutamyl transferase, kolelitiasis

Abstract

Kolelitiasis merupakan salah satu gangguan saluran empedu yang seringkali tanpa gejala sehingga sulit dideteksi dan kerap salah diagnosis. Gaya hidup sedenter diperkirakan menjadi salah satu pemicu utama. Penelitian ini bertujuan untuk menganalisis hubungan antara kolelitiasis dengan kadar bilirubin total, gamma glutamyl transferase (GGT), dan alkaline phosphatase (ALP). Penelitian menggunakan desain potong lintang dengan data rekam medis di RSUD Dr. H. Abdoel Moeloek pada periode 2019–2021. Sampel dipilih secara purposive dari pasien yang memiliki hasil pemeriksaan laboratorium bilirubin total, GGT, ALP, serta pemeriksaan pencitraan abdomen. Total 62 data pasien dianalisis dengan uji Chi Square. Hasil menunjukkan bahwa kolelitiasis berhubungan signifikan dengan peningkatan kadar bilirubin total (p=0,000), GGT (p=0,000), dan ALP (p=0,000). Dengan demikian, kolelitiasis memiliki hubungan bermakna terhadap peningkatan kadar biomarker fungsi hati tersebut.

References

Agganis, B., Lee, D., & Sepe, T. (2018). Liver Enzymes: No Trivial Elevations, Even if Asymptomatic. Cleve Clin J Med, 85(8), 612–617. https://cdn.mdedge.com/files/ s3fs-public/Document/September-2018/agganis_liverenzymes.pdf

Attri, M. R., Kumar, I. A., Din, F. M. U., Raina, A. H., & Attri, A. (2021). Pathophysiology of Gallstones. In Gallstones-Review and Recent Progress. IntechOpen. https://doi.org/10.5772/intechopen.100553

Azriyantha, M. R., & Manjas, A. (2022). Characteristics of Cholelithiasis Patients in Dr. Achmad Mochtar General Hospital Bukittinggi on January 2019-December 2020. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 6(2), 1405–1410. https://doi.org/10.37275/bsm.v6i2.451

Calvaruso, V., Saitta, C., Russello, M., Fichera, A., Bertino, G., Bueti, F. M., Bronte, F., Distefano, M., Giacchetto, M., Salomone, F., Madonia, S., Cadamuro, L., Franzè, M. S., Licata, A., Alaimo, G., Pitrone, C., Minissale, M., Sapienza, M., Cannavò, M. R., & Marco, V. (2022). Gamma Glutamyl Transferase as a Marker of Risk of Progression to Cirrhosis in Patients with Primary Biliary Cholangitis. Digestive and Liver Disease, 54(1), 263–355. https://doi.org/10.1016/j.dld.2022.01.025

Coucke, E. M., Akbar, H., Kahloon, A., & Lopez, P. P. (2022). Biliary Obstruction. StatPearls Publishing.

Dhamnetiya, D., Goel, M. K., Dhiman, B., & Pathania, O. P. (2019). Gallstone Disease and Its Correlates among Patients Attending a Teaching Hospital of North India. Journal of Family Medicine and Primary Care, 8(1), 189–193. https://doi.org/10.4103/jfmpc.jfmpc_358_18

Gu, Q., Zhou, G., & Xu, T. (2020). Risk Factors for Gallstone Disease in Shanghai: An Observational Study. Medicine, 99(3), e18754. https://doi.org/10.1097/MD.00000 00000018754

Ibrahim, M., Sarvepalli, S., Morris-Stiff, G., Rizk, M., Bhatt, A., Walsh, R. M., Hayat, U., Garber, A., Vargo, J., & Burke, C. A. (2018). Gallstones: Watch and Wait, or Intervene. Cleveland Clinic Journal of Medicine, 85(4), 323–331. https://doi.org/10 .3949/ccjm.85a.17035

Jones, M. W., Weir, C. B., & Ghassemzadeh, S. (2022). Gallstones (Cholelithiasis). StatPearls Publishing.

Kalakonda, A., Shanmukhappa, S. K., & Singh, V. (2021). Bilirubin. StatPearls Publishing.

Koenig, G., & Seneff, S. (2015). Gamma Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk. Disease Markers, 2015(1), 818570. https://doi.org/10.1155/2015/818570

Lin, H., Zhou, X., & Zhang, Z. (2022). The Diagnostic Value of GGT Based Biochemical Indicators for Choledocholithiasis with Negative Imaging Results of Magnetic Resonance Cholangiopancreatography. Contrast Media & Molecular Imaging, 2022(1), 7737610. https://doi.org/10.1155/2022/7737610

Littlefield, A., & Lenahan, C. (2019). Cholelithiasis: Presentation and Management. Journal of Midwifery & Women’s Health, 64(3), 289–297. https://doi.org/10.1111/ jmwh.12959

Mei, Y., Chen, L., Zeng, P.-F., Peng, C.-J., Wang, J., Li, W.-P., Du, C., Xiong, K., Leng, K., & Feng, C.-L. (2019). Combination of Serum Gamma-Glutamyltransferase and Alkaline Phosphatase in Predicting the Diagnosis of Asymptomatic Choledocholithiasis Secondary to Cholecystolithiasis. World Journal of Clinical Cases, 7(2), 137. https://doi.org/10.12998/wjcc.v7.i2.137

Notoatmodjo, S. (2018). Metodologi Penelitian Kesehatan (Cetakan II). Rineka Cipta.

Pak, M., & Lindseth, G. (2016). Risk Factors for Cholelithiasis. Gastroenterology Nursing: The Official Journal of the Society of Gastroenterology Nurses and Associates, 39(4), 297–309. https://doi.org/10.1097/SGA.0000000000000235

Rangaswamy, R., Singh, C. G., Singh, H. M., Punyabati, P., & Nyuwi, K. T. (2017). Impact of Biliary Calculi on the Liver. Journal of Clinical and Diagnostic Research: JCDRsearch : JCDR, 11(4), 4–7. https://doi.org/10.7860/JCDR/2017/24680.9738

Stender, S., Frikke-Schmidt, R., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2013). Extreme Bilirubin Levels as a Causal Risk Factor for Symptomatic Gallstone Disease. JAMA Internal Medicine, 173(13), 1222–1228. https://doi.org/10.1001/ jamainternmed.2013.6465

Sugiyono. (2020). Metode Penelitian Kuantitatif Kualitatif dan R&D (Ke-2). Alfabeta.

Tanaja, J., Lopez, R. A., & Meer, J. M. (2022). Cholelithiasis. StatPearls Publishing.