Effects of Breadfruit Leaf Extract in Reducing the Risk of Coronary Heart Disease

  • Laurencia Alimin Fakultas Kedokteran, Universitas Lampung
  • Angwen Rial Huga Fakultas Kedokteran, Universitas Lampung
  • Brigitta Olivia Fakultas Kedokteran, Universitas Lampung
Keywords: breadfruit leaf, flavonoid, coronary heart disease

Abstract

Coronary heart disease (CHD) is the number one cause of death globally, caused by accumulation of plaque, a mixture of fat, cholesterol, and calcium deposits in the arteries for years which over time causes narrowing and hardening of the coronary arteries so that oxygen supply in the blood decreases. CHD can  bepotentiallyprevented  with  active  substancescontained  by  plants  such  as  breadfruit.Breadfruit leaf(Artocarpus altilis) is one of the natural ingredients that contain flavonoids, which can reduce cholesterol, triglycerides and LDL in the blood so the risk of CHD will decrease.Objectiveto  describe  the  potential  anticholesterol effects  of  breadfruit in coronary heart diseasecaused  by high cholesterol. This  paper  used  literature  study  involving  16  libraries  both  nationaland  international  books  and  journal.Conclusions:  Breadfruit leaf has the effect of preventing the risk of coronary heart disease by lowering cholesterol, triglyceride and LDL levels in the blood without side effects.

 Keywords: breadfruit leaf, flavonoid, coronary heart disease

References

Adi PR. 2014. Pencegahan dan Penatalaksanaan Aterosklerosis. Dalam:Setiati, Alwi, Sudoyo. Buku Ajar Ilmu Penyakit Dalam. Edisi Ke-6. Jilid II. Jakarta: Interna Publishing.

Akanni OAAdan Oyebimpe O. 2014. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats.Hindawi Publishing Corporation. 2014(1), 1–11.

Astuti Y, Wahyudi T, Prasetyo A. 2019. Efektifitas Air Rebusan Daun Sukun (Artocarpus altilis) terhadap Penurunan Kadar Kolesterol dalam Darah Mencit (Mus musculus).Jurnal Studi Keperawatan. 1(1), 1–3.

Baixeras SS, Ganella CL, Lucas G, Elosua R. 2014. Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. Appl Clin Genet. 7(1):15-32.

Chronic Disease Management and Control Branch. 2012. Heart Disease and Stroke Prevention Program. 1–8. [Online]. Cited on January 25, 2020 in https://www.cdph.ca.gov.

Estalansa H, Yuniastuti E, Hartati S. 2018. The Diversity of Breadfruit Plants (Artocarpus altilis) based on Morphological Characters.Agrotech Res J. 2(2), 80–85.

Herman SI, Syukri M, Efrida. 2015. Hubungan Faktor Risiko yang dapat Dimodifikasi dengan Kejadian Penyakit Jantung Koroner di RS Dr. M. Djamil Padang Suchi. Jurnal Kesehatan Andalas. 4(2), 369–375.

Jan A and lopez OE. 2019. Cardiovascular Disease. Treasure Island: StatPearls Publishing. [Online]. Cited on February 03, 2020 in https://www.ncbi.nlm.nih.gov/books.

Kementerian Kesehatan Republik Indonesia (Kemenkes RI). 2018. Hasil Utama Riskesdas 2018. Jakarta: Kemenkes RI.

National Heart Foundation of Australia. 2013. Coronary Heart Disease. [Online]. Cited on January 25, 2020 in https://www.heartfoundation.org.au.

National Heart Lung and Blood Institute. 2009. Coronary Heart Disease. [Online]. Cited on January 25, 2020 in https://www.nhlbi.nih.gov.

Pramono A,Kesuma SU, Tazkiana NH, Yunita RA. 2011. Pengaruh Rebusan Daun Sukun (Artocarpus altilis ) terhadap Kadar Trigliserida , Kolesterol Total dan Low Density Lipoprotein (LDL) Serum Darah Tikus Putih (Rattus norvegicus).Mutiara Medika. 11(3), 139–143.

The George Institute for Global Health. 2017. Reducing the burden of Cardiovascular Disease in Indonesia. [Online]. Cited on January 25, 2020 in https://www.georgeinstitute.

Tri EMW, Mukaromah AH, Farabi MF. 2014. Uji Fitokimia Ekstrak Daun Sukun Kering (Artocarpus altilis). Jurnal Unimus.

World Health Organization (WHO). 1996. Risk factor: lipids [Online]. Cited on January 25, 2020 in https://www.who.int.

World Health Organization (WHO). 2017. Cardiovaskular Disease. [Online]. Cited on January 25, 2020 in https://www.who.int.

Published
2020-02-03
How to Cite
Alimin, L., Huga, A., & Olivia, B. (2020). Effects of Breadfruit Leaf Extract in Reducing the Risk of Coronary Heart Disease. Indonesian Journal of Global Health Research, 2(1), 15-22. https://doi.org/10.37287/ijghr.v2i1.60