Orthosiphon Stamineus as Anti-Inflammatory and Diuretic in Gout Arthritis Disease

Dedi Daryanto

doi:10.37287/jppp.v2i3.140

Dedi Daryanto Universitas Lampung

DOI: https://doi.org/10.37287/jppp.v2i3.140

Keywords: anti-inflammatory, gout arthritis, orthosipon stamineus

Abstract

Orthosipon Stamineus or cat's whiskers is one of the herbs that has various pharmacological effects including anti-inflammatory diseases and gout arthritis as a diuretic, so that Orthosipon Stamineus is often used as an herbal remedy. The purpose of this literature review is to know the effect of cat's whiskers plants as anti-inflammatory and diuretic in gout arthritis patients. The sources used are from 21 articles PubMed NCBI, Google Schoolar, and Elsevier, and only 16 articles were used from 1994 to 2019 years. Result of 16 journals called later in the analysis using the Systematic Literature Review method is by collecting, evaluating, and developing research on a particular focus topic. From some research done obtained the result that cat's whiskers plants are beneficial as anti-inflammatory by lowering the formation of TNFa and IL1. The active compounds of flavonoids and phenolic that are found in Orthosipon Stamineus can suppress inflammatory reactions and contain diuretic compounds that lower purine levels in the body.

References

Afnuhazi, R. (2019). Faktor-faktor yang berhubungan dengan kejadian gout pada lansia. Jurnal Human Care, 34-41.

Alfaridz, F., & Amalia, R. (2018). Review Jurnal : Klasifikasi Dan Aktivitas Farmakologi Dari Senyawa Aktif Flavonoid. Farmaka, 16(3). https://doi.org/10.24198/jf.v16i3.17283.g8932

Arafat, M. O., & Tham, S. Y. (2008). Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats. Journal of Ethnopharmacology, 354-360. https://doi.org/10.1016/j.jep.2008.04.015

Frondoza, C. (2004). An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. In Vitro Cell Dev Biol Anim, 95-101.

Ibrahim, Rahayunigrum, D. C., & Lesmana, I. (2019). Reaction Of Orthosiphon Aristatus To Acid Contents Blood-Vessel Patient Of Gout Atritis. Kesehatan Saintika Meditory, 4(3), 33-43.

Jung HA, e. (2003). inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation. Arch. Pharm. Res, 26, 809–815.

Laavola, M. (2012). Flavonoids Eupatorin and Sinensetin Present in Orthosiphon stamineus Leaves Inhibit Inflammatory Gene Expression and STAT1 Activation (Vol. 4). Stuttgart: University of Tampere School of. http://dx.doi.org/10.1055/s-0031-1298458

Madeswaran, A., Umamaheswari, M., Asokkumar, K., & et,al. (2012). .Discovery of potential cyclooxygenase inhibitors using in silico docking studies. Bangladesh J. pharmacol, 7, 21-27.

Sangeetha S.K, e. (2016). Flavonoids :Therapeutic Potential of Natural Pharmacological Agents. Int. J. Pharm Sci. Res, 7, 3924–3930.

Selbert K, e. (1994). Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sc, 91(25).

Songgigilan, A., Rumengan, I., & Kundre, R. (2019). Hubungan Pola Makan Dan Tingkat Pengetahuan Dengan Kadar Asam Urat Dalam Darah Pada Penderita Gout Artritis Di Puskesmas Ranotana Weru. e-journal Keperawatan.

Tabana, Y. M., Saleih, F., & Ahmeed, M. K. (2016). Cat’s whiskers (Orthosiphon stamineus) tea modulates arthritis pathogenesis via the angiogenesis and inflammatory cascade. Complementary and Alternative Medicine. DOI 10.1186/s12906-016-1467-4

Tehupeiory, E. (2006). Artritis Gout . In Buku Ajar Ilmu Penyakit Dalam (pp. 1208-1210). Jakarta: FKUI.

Widyanto, F. W. (2017). Artritis Gout Dan Perkembangannya. saintika medika, 10(2):145-152.

Wilson, L., & Saseen, J. J. (2016). Gouty Arthritis: A Review of Acute Management and Prevention. Pharmacotherapy.

Zhong, Y. S. (2012). Prophylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats. Journal of Ethnopharmacology, 761-767. https://doi.org/10.1016/j.jep.2012.09.052