Clinical Characteristics of Coronavirus Disease 2019
Abstract
The COVID-19 took the world by storm and has become a pandemic. It was first reported in Wuhan, Hubei province, China in December 2019. This virus is a new type of coronavirus. COVID-19 is caused by SAR-CoV2. The purpose of this study was to determine the clinical characteristics of COVID-19 including clinical symptoms and the tests used to confirm the disease. The research method used is literature review by collecting 25 journals from 2020, these journals were collected from various sources, namely Pubmed, Medscape, Google scholar and WHO, and only 22 articels were used in this study. The results obtained from this study are that it is known that the symptoms of COVID-19 are not specific and initially only mild symptoms such as fever, cough and fatigue and appear gradually. This disease can be confirmed using the rRT-PCR method, besides that a chest CT scan can also be done as a diagnostic test for COVID-19.
References
Badan Nasional Penanggulangan Bencana. (2020). Situasi Virus Corona. Jakarta: Badan Nasional Penanggulangan Bencana
Chan, J. F., Yuan, S., Kok, K. H., To, K. H. K., Chu, H., Yang, J., … & Yuen, K. Y. (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet, 395(10223), 514-523. https://doi.org/10.1016/S0140-6736(20)30154-9
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., … & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507-513. https://doi.org/10.1016/S0140-6736(20)30211-7
Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., … & Shan, H. (2020). CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology, 295(1), 202-207. https://doi.org/ 10.1148/radiol.2020200230
Gralinski, L. E., & Menachery, V. D. (2020). Return of the Coronavirus: 2019-nCoV. Viruses, 12(2), 135. https://doi.org/ 10.3390/v12020135
Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X., … & Li, L. J. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med, 382(18), 1708-1720. https://doi.org/ 10.1056/NEJMoa2002032
Holshue, M. L., DeBolt, C., Lindquist, S., Lofy, K. H., Wiesman, J., Bruce, H., … & Pilai, S. K. (2020). First Case of 2019 Novel Coronavirus in the United States. N Engl J Med, 382(10), 929-936. https://doi.org/ 10.1056/NEJMoa2001191
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., … & Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published correction appears in Lancet. 2020 Jan 30;:]. The Lancet, 395(10223), 497-506. https://doi.org/ 10.1016/S0140-6736(20)30183-5
Lei, J., Li, J., Li, X., & Qi, X. (2020). CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology, 295(1), 18. https://doi.org/10.1148/radiol.2020200236
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., … & Ren, R. (2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med, 382(13), 1199-1207. https://doi.org/ 10.1056/NEJMoa2001316
Li, K., Wu, J., Wu, F., Guo, D., Chen, L., Fang, Z., & Li, C. (2020). The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia. Investigative Radiology, 55(6), 327-331. https://doi.org/ 10.1097/RLI.0000000000000672
Li, X., Geng, M., Peng, Y., Meng, L., & Lu, S. (2020). Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal, 10(2), 102-108. https://doi.org/ 10.1016/j.jpha.2020.03.001
Li, Y., & Xia, L. (2020). Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management. AJR Am J Roentgenol, 214(6), 1280-1286. https://doi.org/ 10.2214/AJR.20.22954
Liu, S., Luo, H., Wang, D., Ju, S., & Yang, Y. (2020). Characteristics and Associations with Severity in COVID-19 : a multicentre cohort study from Jiangsu province, China. The Lancet.
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., … & Peng, Z. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 323(11), 1061-1069. https://doi.org/ 10.1001/jama.2020.1585
Wang, W., Tang, J., & Wei, F. (2020). Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China. J Med Virol, 92(4), 441-447. https://doi.org/ 10.1002/jmv.25689
World Health Organization. (2020). Coronavirus disease (COVID-2019) situation reports. New Delhi. SEARO
Wang, W., Xu, Y., Gao, R., Lu, R., Han, K., Wu, G., & Tan, W. (2020). Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA, 323(18), 1843-1844. https://doi.org/ 10.1001/jama.2020.3786
Xu, X. W., Wu, X. X., Jiang, X.G., Xu, K. J., Ying, L. J., Ma, C. L. (2020). Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ, 368, m606. https://doi.org/ 10.1136/bmj.m606
Yang, W., Cao, Q., Qin, L., Wang, X., Cheng, Z., Pan, A. (2020). Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China. J Infect, 80(4), 388-393. https://doi.org/ 10.1016/j.jinf.2020.02.016
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., … & Shang, Y. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med, 8(5), 475–81. https://doi.org/ 10.1016/S2213-2600(20)30079-5
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., … & Tan, W. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med, 382(8), 727-733. https://doi.org/ 10.1056/NEJMoa2001017



