Analysis of Maternal Death Based on Cycle Threshold Polymerase Chain Reaction Values in Pregnant Women Confirmed with COVID-19
Abstract
COVID-19 is an infectious disease caused by SARS-CoV-2. COVID-19 infect all groups, including pregnant women, resulting in a high positive rate pregnant women. COVID-19 diagnosis process can be supported by RT-PCR test. The RT-PCR test there is a CT-Value which is used to see the viral load which can affect the severity of COVID-19, including pregnant women who experience physiological changes in the body that can lead to maternal death. The purpose of this study was to analyze CT-Value RT-PCR on maternal mortality. This research is an observational analytic study with a cross-sectional approach. The sampling technique used was total sampling. The number of samples were 76 pregnant women with COVID-19 at Abdul Moeloek Regional General Hospital, Lampung Province period March 2020-October 2021. The number of pregnant women who died due to COVID-19 at Abdul Moeloek Hospital, Lampung Province period March 2020-October 2021, was 12 (15.8%) of all pregnant women who were confirmed COVID-19, namely 76 patients. In the statistical test, the p-value was 0.211 (p>0.05), it was concluded that the CT-Value of pregnant women with COVID-19 did not affect maternal mortality. Maternal mortality is not affected by CT-Value PCR pregnant women with confirmed COVID-19.
References
Bedford, J., Enria, D., Giesecke, J., Heymann, D. L., Ihekweazu, C., Kobinger, G., Lane, H. C., Memish, Z., Oh, M. D., Sall, A. A., Schuchat, A., Ungchusak, K., Wieler, L. H., & WHO Strategic and Technical Advisory Group for Infectious Hazards (2020). COVID-19: towards controlling of a pandemic. Lancet (London, England), 395(10229), 1015–1018. https://doi.org/10.1016/S0140-6736(20)30673-5
Camargo, J. F., Lin, R. Y., & Komanduri, K. V. (2021). Lack of correlation between the SARS-CoV-2 cycle threshold (Ct ) value and clinical outcomes in patients with COVID-19. Journal of medical virology, 93(10), 6059–6062. https://doi.org/10.1002/jmv.27171
Choudhuri, J., Carter, J., Nelson, R., Skalina, K., Osterbur-Badhey, M., Johnston, A., Goldstein, D., Paroder, M., & Szymanski, J. (2020). SARS-CoV-2 PCR cycle threshold at hospital admission associated with patient mortality. PloS one, 15(12), e0244777. https://doi.org/10.1371/journal.pone.0244777
Destylya, D. (2021). Karakteristik Pasien Covid-19 Di Rumah Sakit Umum Pusat Haji Adam Malik Medan Sumatera Utara.
Kapoor, M., Kalita, D., & Panda, P. K. (2021). Cycle threshold values versus reverse transcription-polymerase chain reaction positivity in COVID-19 de-isolation. Indian journal of medical microbiology, 39(1), 133–135. https://doi.org/10.1016/j.ijmmb.2020.12.009
Kementerian Kesehatan RI. 2021. COVID-19 dalam Angka [Online] [diakses 11 September 2021]. Tersedia dari: https://www.kemkes.go.id/resources/download/info-terkini/covid%20dalam%20angka/covid-dalam-angka-26062020.pdf
Kementerian Kesehatan RI. 2021. COVID-19 dalam Angka [Online] [diakses 11 September 2021]. Tersedia dari: https://www.kemkes.go.id/resources/download/info-terkini/covid%20dalam%20angka/covid-dalam-angka-26062020.pdf.
La Scola, B., Le Bideau, M., Andreani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020). Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(6), 1059–1061. https://doi.org/10.1007/s10096-020-03913-9
Magleby, R., Westblade, L. F., Trzebucki, A., Simon, M. S., Rajan, M., Park, J., Goyal, P., Safford, M. M., & Satlin, M. J. (2021). Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients With Coronavirus Disease 2019. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73(11), e4197–e4205. https://doi.org/10.1093/cid/ciaa851
POGI. (2020). Rekomendasi penanganan infeksi virus corona (COVID-19) pada maternal (hamil, bersalin, dan nifas). Jakarta : Perkumpulan Obstetri dan Ginekologi Indonesia, Pokja Infeksi Saluran Reproduksi.
Rao, S. N., Manissero, D., Steele, V. R., & Pareja, J. (2020). A Systematic Review of the Clinical Utility of Cycle Threshold Values in the Context of COVID-19. Infectious diseases and therapy, 9(3), 573–586. https://doi.org/10.1007/s40121-020-00324-3
Wang, D., Yin, Y., Hu, C., Liu, X., Zhang, X., Zhou, S., Jian, M., Xu, H., Prowle, J., Hu, B., Li, Y., & Peng, Z. (2020). Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. Critical care (London, England), 24(1), 188. https://doi.org/10.1186/s13054-020-02895-6
Zaigham, M., & Andersson, O. (2020). Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta obstetricia et gynecologica Scandinavica, 99(7), 823–829. https://doi.org/10.1111/aogs.13867
Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., Xia, S., & Zhou, W. (2020). Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational pediatrics, 9(1), 51–60.
![88+ Daftar Jurnal Sinta 5 Gratis Yang Terbit Bulan Ini? [Update 2022]](https://stiqwalisongo.ac.id/wp-content/uploads/2020/10/sinta-5.jpg){kind=small}
